Crescent Discovery Series

A reading room for breakthroughs and the curious mind

C-section babies were swabbed with their mother's bacteria

Babies born by cesarean section skip the trip through the birth canal that normally hands them their first bacteria.

Crescent Bioresearch9 July, 11:11 AMDominguez-Bello et al., Nature Medicine, 2016 · New York University School of Medicine2 min read

That missed exposure has been linked to a higher risk of immune and metabolic problems later in life. Researchers at New York University tested whether simply wiping a newborn with gauze soaked in the mother's vaginal fluid could restore some of what the birth canal would have provided.

In a pilot study, four infants delivered by cesarean were swabbed with their mother's vaginal fluid shortly after birth. Over the next month, their gut, mouth, and skin bacteria grew enriched with vaginal bacteria largely absent in unexposed cesarean-born infants, moving closer to the pattern seen in vaginally delivered babies.

The procedure did not fully recreate a vaginal birth's microbial exposure, and whether it changes a child's long-term risk of asthma, allergy, or obesity is still unknown, since the pilot was not designed or sized to answer that question. Larger, randomized follow-up studies were needed before the practice, sometimes called vaginal seeding, could be recommended.

Crescent Discovery Series cover: C-section babies were swabbed with their mother's bacteria

A birth canal, approximated with a swab.

Source

  1. Dominguez-Bello, M. G., De Jesus-Laboy, K. M., Shen, N., Cox, L. M., Amir, A., Gonzalez, A., Bokulich, N. A., Song, S. J., Hoashi, M., Rivera-Vinas, J. I., Mendez, K., Knight, R., & Clemente, J. C. (2016). Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer. Nature Medicine, 22(3), 250–3. https://doi.org/10.1038/nm.4039
Crescent Discovery Series

Follow the series

New discoveries are published on our channels every day.

Keep going

Three more numbers