A team led from the University of Limerick pooled randomized trials that compared sitting through a day against breaking it up with short bouts of standing or light walking, then combined the results on blood sugar.
Across seven trials of adults who were mostly overweight or living with obesity, interrupting sitting with light walking lowered the after-meal rise in blood glucose more than standing breaks did, and cut insulin too across four pooled trials. Neither walking nor standing changed systolic blood pressure across three.
The reviewers could not say exactly how short or how frequent a walk needs to be for the full effect, since the seven trials varied in walk length and timing. Even so, the pattern held across different protocols and populations, suggesting short walking breaks do real metabolic work that a chair cannot.

Read the original study
Buffey et al., Sports Medicine, 2022 · doi.org/10.1007/s40279-022-01649-4
Standing up is good. Walking is better.
Source
- Buffey, A. J., Herring, M. P., Langley, C. K., Donnelly, A. E., & Carson, B. P. (2022). The Acute Effects of Interrupting Prolonged Sitting Time in Adults with Standing and Light-Intensity Walking on Biomarkers of Cardiometabolic Health in Adults: A Systematic Review and Meta-analysis. Sports Medicine, 52(8), 1765–1787. https://doi.org/10.1007/s40279-022-01649-4