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A newborn's heart fully recovered after a heart attack

Adult hearts scar after a heart attack and never regrow the muscle they lose.

Crescent Bioresearch15 September, 11:32 AMHaubner et al., Circulation Research, 2016 · Medical University of Innsbruck2 min read

Mouse studies had shown that a newborn mouse heart can regenerate completely if injured in its first week of life, a window that closes fast. Whether a human newborn had any of that same capacity was still an open question.

Doctors in Innsbruck, Austria documented a newborn who suffered a severe heart attack from a blocked coronary artery, with imaging and blood markers confirming massive damage to her heart muscle. Within weeks the child's heart function returned to normal and stayed normal on long-term follow-up.

It is a single documented case, not a trial, so it cannot prove how common this capacity is or how long the window lasts in people. But it lined up with the mouse data closely enough that researchers now treat early infancy as a plausible, narrow opportunity for the human heart to repair itself before that ability fades.

Crescent Discovery Series cover: A newborn's heart fully recovered after a heart attack

A newborn heart, fully recovered.

Source

  1. Haubner, B. J., Schneider, J., Schweigmann, U., Schuetz, T., Dichtl, W., Velik-Salchner, C., Stein, J.-I., & Penninger, J. M. (2016). Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circulation Research, 118(2), 216–21. https://doi.org/10.1161/CIRCRESAHA.115.307017
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