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A mother's brain can carry her son's DNA for decades

During pregnancy, cells from a fetus slip into the mother's bloodstream and travel throughout her body.

Crescent Bioresearch30 June, 3:13 PMChan et al., PLoS ONE, 2012 · Fred Hutchinson Cancer Research Center2 min read

Researchers at the Fred Hutchinson Cancer Research Center in Seattle searched for male DNA, which can only have come from a male fetus, in brain tissue donated by women after death.

Using a sensitive genetic test for a Y-chromosome marker, the team found male DNA scattered across multiple brain regions in 37 of 59 women studied, about 63 percent. The oldest woman with male DNA in her brain had died at 94.

Women with Alzheimer's disease tended to have lower rates and concentrations of this male DNA in their brains than women without the disease, though the study could not determine whether that difference was a cause of the disease or simply a result of it. Fetal cells have also been found in other maternal organs and are being studied for a possible role in both disease and tissue repair.

Crescent Discovery Series cover: A mother's brain can carry her son's DNA for decades

Her child's cells, still living inside her.

Source

  1. Chan, W. F. N., Gurnot, C., Montine, T. J., Sonnen, J. A., Guthrie, K. A., & Nelson, J. L. (2012). Male microchimerism in the human female brain. PLOS ONE, 7(9), e45592. https://doi.org/10.1371/journal.pone.0045592
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