Crescent Discovery Series

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A failed bacteria experiment led to a 95 percent cure

Barnett Rosenberg was a physicist, not an oncologist, running current through bacteria in a Michigan lab.

The Crescent Team21 June, 11:00 AMEinhorn et al., Annals of Internal Medicine, 1977 · Indiana University School of Medicine2 min read

In 1965 he noticed the bacteria stopped dividing near platinum electrodes in the solution. The current itself was not the cause. A corrosion product of the platinum was, and it was later named cisplatin.

Physicians at Indiana University tested the compound in young men with metastatic testicular cancer, a disease that killed most patients within a year. Lawrence Einhorn combined cisplatin with vinblastine and bleomycin, and complete remission rates jumped from under 10 percent to more than 70 percent in the first trial.

Dosing was refined through the late 1970s to cut toxicity without losing effect, and testicular cancer, once a near certain death sentence for young men, became one of oncology's most curable solid tumors, with cure rates now cited above 90 percent when caught early. The same platinum chemistry still anchors regimens for ovarian, lung, and head and neck cancers today.

Crescent Discovery Series cover: A failed bacteria experiment led to a 95 percent cure

A corroded platinum wire built a cure.

Source

  1. EINHORN, L. H., & DONOHUE, J. (1977). <i>Cis</i>-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer. Annals of Internal Medicine, 87(3), 293–298. https://doi.org/10.7326/0003-4819-87-3-293
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